The discovery of IP3 as the calcium-mobilizing second messenger
"With Robin's verified stock of inositol 1,4,5-trisphosphate; the calcium-mobilising form of IP3, Irene's permeabilized cells (质膜通透的大鼠胰腺腺泡细胞) and her post-doc Hans-Peter Streb performing the experiments, it was straight forward to show that IP3 selectively evoked calcium release from a non-mitochondrial calcium store (内质网钙库).
... , Mike and Robin convey the excitement around this major discovery in a brief video (https://www.youtube.com/watch?v=iyIdLi1yIIo)."(你如果能看到“油管”的话)
Photo: Mike J. Berridge with Irene Schulz and Robin Irvine, depicting the discovery of the calcium mobilizing ability of IP3, used by Michael J. Berridge in his lectures.
参考文献：
Streb H, Irvine RF, Berridge MJ, Schulz I (1983) Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature 306: 67-69. A total of 2, 051 cites on 31-03-2021. (原始论文被引用超过2, 000次)
以上英文文字及图片均引自：
Bootman MD, Galione A, Taylor CW (2021) A tribute to Professor Sir Michael J. Berridge FRS (1938–2020). Biochim Biophys Acta - Mol Cell Res 1868: 119014. Published May 2021.
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